Most of the SciCompiler supported board require fully differential signaling to correct operate. Differential signaling is a method for electrically transmitting information using two complementary signals. The technique sends the same electrical signal as a differential pair of signals, each in its own conductor. The receiving circuit responds to the electrical difference between the two signals, rather than the difference between a single wire and ground. Provided that the source and receiver impedances in a circuit are equal (it is balanced), external electromagnetic interference tends to affect both conductors identically. Since the receiving circuit only detects the difference between the wires, the technique resists electromagnetic noise compared to one conductor with an un-balanced reference (low-Ω connection to ground). Due to immunity to the noise, differential signals allows to transport the analog signals from tens of meters on standard and cheap CAT5e/CAT6 cables without any signal degradation. This application notes include information and circuit to convert single ended signal from radiation detector to signal that can be easy digitalized with the DT5500 or R5560.